This study aimed to explore the impact of entrepreneurship strategies on competitive advantage in Palestinian universities in the southern governorates. The research problem was summarized in the existence of some incapacity among public and private institutions to absorb more jobs, and some shortcomings in the performance of universities in developing entrepreneurial projects. The researcher used the descriptive-analytical approach, and a questionnaire was designed as a tool for data collection. The researcher used a stratified random sample of (329) academics and administrators, and the data were analyzed using the (SPSS) program. The study revealed a set of results, the most important of which are: • The reality of implementing entrepreneurship strategies in Palestinian universities, with its dimensions (innovation, creativity, opportunity seeking, risk initiative, and uniqueness), reached a percentage of (77.6%), while the degree of achieving competitive advantage reached a percentage of (75.2%), and the reality of implementing sales development in Palestinian universities reached a percentage of (76.8%). • This study proved that there is a statistically significant impact at the significance level (α≤0.05) of entrepreneurship strategies on competitive advantage, and it also showed that there is a statistically significant impact at the significance level (α≤0.05) of entrepreneurship strategies on the development of their services and sales. The study recommended a set of recommendations, the most important of which are: • The necessity for universities to take appropriate decisions when performing duties and tasks with the least amount of risk in order to face emergency conditions. It should also work to attract creative human competencies in various fields to achieve competitive advantage and increase their market share. • The study also recommended that universities focus on seeking the assistance of experts when formulating their plans for improving and enhancing competitive advantage in order to increase the efficiency of services and develop them.............. Keywords: .............Strategy, Entrepreneurship, Entrepreneurship Strategies.