AMR is a critical global health threat, particularly in regions with limited surveillance data. This study aimed to investigate the prevalence of common enteric bacteria and their antimicrobial susceptibility patterns among patients in Sabratha, Libya, to provide essential local data for clinical guidance and public health strategy. A cross-sectional study was conducted on 50 patients attending Al-Razi Laboratory medical laboratories in Sabratha. Bacterial isolates were identified using standard microbiological procedures. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method according to CLSI guidelines for a panel of commonly used antibiotics. Data on patient demographics, bacterial species, and resistance patterns were analyzed. The 50 infections were caused equally by Streptococcus spp. (n=25, 50%) and Escherichia coli (n=25, 50%). A significant gender disparity was observed, with females accounting for 76% (n=38) of cases. E. coli showed the highest sensitivity to Ciprofloxacin (34%), while Streptococcus was most sensitive to Levofloxacin (36%). Concerning resistance rates were noted; for instance, E. coli showed 16% resistance to Nalidixic acid, and Streptococcus showed 12% resistance to Amoxicillin. Overall, 70% of isolates were resistant to at least one antibiotic, and 18% met the criteria for multidrug resistance (MDR), being resistant to three or more antibiotic classes. This study reveals a significant burden of E. coli and Streptococcus infections in Sabratha, with a higher prevalence among females. The observed antimicrobial resistance, including notable MDR rates, highlights an urgent need for establishing local antimicrobial stewardship programs, enhancing surveillance, and promoting rational antibiotic use to preserve the efficacy of essential medicines in the region................. Keywords:............... Antimicrobial resistance, Enteric bacteria, Sabratha, Libya, Antibiotic susceptibility.