The role of skin in fish is important providing mutli-physiological functions to fishes in surrounding environmental. In this study used rotary microtome, routine procedures of tissues preparation were followed and paraffin blocks were cut at 4µm, stained with Hematoxylin and eosin (H&E) and microscope with digital camera to studdy skin of Mullatus barbatus and Scomperscombrus.The currently study showed that, skin is composed of three tissue layers; epidermis, dermis and subcutis. Histological and morphometric studies revealed the epidermis and dermis of S. scombrus were 71.21±5.21 µm, 171.33±10.21 μm in thickness compare with M. barbatus which were 6.85±0.05 μm, 92.51±7.11 μm respectively. While the thickness of the subcutes layer in M. barbatus (501.65±27.81 μm) compared with S. scombrus (174.02±15.34 μm). Furthermore, A spread of electroreceptor in skin of M. barbatusw as observed, in addition to the presence of scale pockets in the dermis of the skin of S. scombrus. The structural variations of skin of fishes may reflect the various environmental difficulties that they confront. Histological study of fish skin contributes to understanding adaptations to life in the surrounding aquatic environment Keywords: Fishes, Skin, Epidermis, Dermis, Subcutes.