This study aims to analyze the geographical distribution of diseases in the municipality of Zliten based on data of cases visiting the Zliten Medical Center and to reveal the demographic characteristics of these cases. As well as to find out the relationship between the independent and dependent variables associated with these diseases, by finding the value of the chi-squared cell and its level of statistical significance. The study adopted the statistical method with regard to statistical significance tests of differences to determine whether the differences between the group means were real or due to chance. The study reached several conclusions, most notably: natural factors play a direct role in the spread of many diseases, in addition to the high levels of pollution resulting from human activities. The results also showed statistically significant relationships (α = 0.05) between most of the study variables and disease incidence in study area. Furthermore, some variables did not show statistically significant relationships with disease incidence Additionally, rural centers showed a statistically significant relationship only with the gender variable, and a higher incidence of disease among the elderly, particularly those aged 46 and over. The study recommended allocating specific areas for industrial activities away from residential areas, enacting laws and implementing regulations to reduce pollution from factories, raising public health awareness............ Key Words............ Geographical distribution, hesitant cases, urban centers, study variables.