This study intends to analyze the role of human resource management (HRM) practices in the context of fostering sustainable development in charitable organizations in the Gaza Strip. The study emanates from a basic issue: the lack of clarity regarding the relationship between HRM practices and their effect on the sustainability of charities' operations, especially given the financial and administrative constraints they face. A descriptive-analytic approach was adopted, and data was collected via an electronic questionnaire given to 232 male and female employees. The questionnaire dealt with four main areas: recruitment and appointment, training and development, performance evaluation, and rewards and compensation; it also covered measuring sustainable development. The results revealed that the level of HR management practices was high in every domain, among them which training and development and recruitment and appointment had the highest impact on sustainable development. The study also found that good success in the practice contributes to increasing institutional performance and ensuring the continuity of the services offered by various charities effectively. Keywords: human resource management, sustainable development, charitable organizations, Gaza Strip