This study aimed to examine the role of knowledge management in enhancing strategic success within Palestinian universities in the southern governorates of Palestine. The study adopted the descriptive-analytical approach and utilized a questionnaire as the primary instrument for data collection. The study sample consisted of 239 male and female employees occupying senior supervisory positions in Palestinian universities. The findings revealed a high level of knowledge management implementation and demonstrated a statistically significant effect of knowledge management dimensions on achieving strategic success, with a relative weight of 81.1%. The results also highlighted the importance of knowledge diagnosis and utilization in improving institutional performance and enhancing responsiveness to environmental changes. The study recommended supporting organizational learning, strengthening employee participation in decision-making, developing technological and knowledge infrastructures, attracting qualified academic competencies, supporting research and development activities, and improving academic programs in line with community needs and institutional development requirements.......... Keywords:........Knowledge Management, Strategic Success, Academic Leadership, Palestinian Universities.