This research explores human biopiracy and its development, from the misuse of physical samples to digital piracy utilizing open-access Digital Sequence Information (DSI)of human genomes from developing countries. Using a critical analytical approach, it examines this phenomenon under public international law, with an emphasis on state sovereignty and genetic privacy. The study investigates whether current global accords—such as UNESCO declarations and intellectual property treaties—can help to prevent this abuse, which masquerades as patents and free research. The study suggests creating a binding international treaty to ensure digital genetic sovereignty and outlaw modern genetic colonialism, thereby closing a legislative gap that permits exploitation without prior informed consent or fair benefit-sharing................ Keywords: .............Human Biopiracy; Digital Genetic Sovereignty; Digital Sequence Information (DSI); Developing Nations; International Bioethics Law.