المجلة الدولية للعلوم والتقنية

Diabetes mellitus is the most common metabolic disease. Obesity is a physiological variant which leads to various pathological complications including Type-II diabetes mellitus. Type-II diabetes mellitus, obesity and dyslipidemia are considered as independent risk factors for coronary heart disease and cerebrovascular disease. In this study is to compare lipid profile in Type-II diabetics with obesity & overweight and non diabetic obese & overweight people, the control group. This study enrolled 48 obese & overweight Type-II diabetes mellitus patients and 25 obese & overweight non diabetic controls of age 30-84 yrs and this study, in (Diabetes & Endocrinology Center Hospital Tripoli – Libya) were chosen. FBS, HbA1c and serum lipid levels were analyzed in patients. Serum Lipids and glucose were measured by enzymatic method COBAS INTEGRA. HbA1c was measured by immunoturbidimetrically COBAS INTEGRA. Statistical analysis was carried out using standard deviation and chi-square from which ‘p’ value is derived, ‘p’ value <0.05 is significant. Among 48 obese& overweight diabetic new patients triglyceride levels were increased in 17 new patients, total cholesterol levels were increased in 17 new patients; LDL-C levels were increased in 31 new patients and HDL-C levels were decreased in 44 new patients. This showed not significantly triglycerides, LDL-C and low HDL-C in type-II diabetes mellitus with obesity& overweight when compared to healthy control group; there was no significant change in total cholesterol levels between the two groups. This study showed strong evidence of Type-II diabetes mellitus associated with obesity leading to high levels of lipids which aggravate the atherogenic process, leading to increased morbidity and significant mortality compared to non diabetes obese population. As diabetes is a chronic disease intensive and prolonged medical management is required along with hypolipidaemic drugs.