Smoking tobacco is considered the worst human habit. Many harmful chemicals included in cigarettes have been connected to specific types of cancer. Numerous biochemical and hematological processes can be disrupted by cigarette smoking, according to laboratory tests. Determining the influence of tobacco use on some blood in males in Al-Bayda City, Libya, is the goal of the current study. 119 people, aged 20 to 55, participated in the study; 61 of them smoked, while the remaining 58 did not. They surveyed from October 20, 2023, until January 30, 2024. The smokers' durations ranged from six months to forty years. The participants were free of major health conditions, had never used drugs, and had not given or received blood in the previous six months. Medical data, health histories, and other relevant information were collected from participants through in-person interviews. The findings demonstrated that there were considerable alterations in the hematological parameters of experimental males, including MCV, MCHC, WBC, LYM, MON, GR, PCT, MPV, RDW-1, and PDW. The PLT was meaningfully lower in smokers than in non-smokers, but there was no important difference in the RBC, HGB, MCH, RDW, HCT, MPV, or PDW. The current study concluded that there were noteworthy differences between smokers and non-smokers in some hematological parameters. These differences may be associated with several future diseases, including an increase in atherosclerosis, PV, COPD, and/or CVDs................. Keywords: ..............Cigarettes; hematology; males, El Bayda, smoke