Orange fruits are susceptible to many fungal diseases that lead to their spoilage, especially during the collection and marketing stages. The most prominent of these diseases is green mold, caused by the fungus Penicilliumdigitatum. This study aims to investigate the potential of alcoholic extract of Ziziphusspina-christi and the Trichodermaharzianum fungus as biological control against P. digitatum fungus. Materials and Methods : Trichodermaharzianum and Ziziphusspina-christi extract (50% concentration) were used to study their effect on the growth of the pathogenic fungus P. digitatum. Results: T. harzianum inhibited the growth of the pathogenic fungus P. digitatum growing on orange fruits in 7 days of incubation up to 77.96%. As for the extract of Ziziphusspina-christi, it reached a rate of inhibition of 82.50%. Discussion: The research results showed that the use of biological control methods using microorganisms and plant extracts was effective in combating diseases that affect plant crops and limiting their losses. Recommendations: Completing the research by conducting field experiments with isolates of microorganisms and natural plant extracts............. Keywords:........... Trichodermaharzianum, Ziziphusspinachristi (L), Pe nicilliumdigitatum.