An experiment was conducted in the Grain Technology Laboratory، Department of Crops, Faculty of Agriculture, Omar Al-Mukhtar University, during the winter season (2021–2022). A factorial experiment in a Completely Randomized Design (CRD) was used with three replications. The treatments included seed soaking for 24 hours and foliar application of different concentrations of copper sulfate (0.5, 1, 1.5, and 2 g/L) compared with the control, in order to evaluate its efficiency in improving seedling characteristics and growth of wheat (Triticum aestivum, Kasy cultivar). Measurements were taken during the seedling growth stage. The results clearly showed that both the method of treatment and copper sulfate concentrations had a significant effect on all studied traits of wheat, including germination percentage, root length, plumule length, seedling length, fresh weight, dry weight, leaf area, and growth rate. Foliar application outperformed seed soaking in all traits and recorded the highest values for most growth parameters. The results also indicated that the concentration of 2 g/L of copper sulfate achieved the best response in most traits, leading to significant increases in germination percentage, root and shoot growth, and biomass accumulation. Furthermore, the interaction between foliar spraying and the 2 g/L concentration showed a clear superiority across all studied traits, indicating a synergistic effect between application method and concentration. In general, the findings suggest that foliar application of copper sulfate at an appropriate concentration enhances plant physiological processes such as photosynthesis and metabolism, which in turn improves early growth and increases the efficiency of biomass production in wheat............ Keywords:............ Copper Sulfate (CuSO₄), Wheat Crop (Kassi Cultivar) , Foliar Application, Seed Soaking