Jaundice can be an indicator of significant underlying disease. It is caused by elevated serum bilirubin levels in the unconjugated or conjugated form. The evaluation of jaundice relies on the history and physical examination. The main aim of this article was to determine the incidence and prevalence of disease in the two groups compared. In this cross-sectional study, during the period from 2014 to 2019, the collection of data was based on the Medical Care Unit (MCU) at Al-Bayda medical center (AMC) in Libya. Among this study, the prevalence of jaundice in aged ≥20 years was (173) 17.59 %. The sex distribution of jaundice cases aged ≥20 years was 60.1156% (104) women and 39.8843% (69) men. In the majority of patients, the incidence caused over all patients was in-hepatic jaundice (67.056%). This included hepatitis 33/173 (19.07%), in which the female was 21.97% and the male was 16.04%, and liver cirrhosis 83/173 (47.97%), in which the female was 49.50% and the male was 45.67%. In addition to the second factor, which was post-hepatic jaundice, 18.49% over all, the third factor was pre-hepatic jaundice, 14.45%.