The current investigation aimed to determine if Panax ginseng might shield male rabbit liver against stannous chloride (SnCl₂)-induced liver damage. 20 rabbits were randomly divided into 4 equal-sized groups comprising 5 rabbits each. The first group (control) was given the same amount of corn oil only. The effects of P. ginseng (100 mg per kg of body weight) and SnCl₂ (20 mg per kg of body weight) were investigated in the second and third groups, respectively. The impact of P. ginseng + SnCl₂ was investigated in the fourth group. For 12 weeks, the animals received oral treatment every day. The findings indicated that "AST, ALT, and ALP" activities in the liver were considerably "P < 0.05" raised by P. ginseng, although serum "AST, ALT, and ALP" activities were dramatically decreased by P. ginseng therapy alone. On the other hand, compared to the control, SnCl₂ considerably "p < 0.05" decreased "AST and ALT" activities in the liver's plasma while considerably "p 0.05", raising levels of "AST, ALT, and ALP" activities. Following P. ginseng therapy, the levels of "T. bilirubin" were considerably "P < 0.05" lower. However, treatment with SnCl₂ significantly increased levels of "T. bilirubin". Administration of P. ginseng in combination with SnCl₂ minimized and alleviated the hazardous effect of SnCl₂ on most of the measured parameters. In conclusion, P. ginseng could effectively protect against stannous chloride (SnCl₂) toxicity..................... Keywords:................Stannous chloride; Panax ginseng; AST; ALT; ALP; Male rabbit liver.