Cannabis, a plant rich in cannabinoid compounds such as tetrahydrocannabinol (THC) and cannabidiol (CBD), has attracted significant interest due to its medical applications and psychoactive/addictive effects. This study aimed to investigate the association between cannabis use and oral health by examining the growth of Lactobacillus bacteria and Candida albicans among addicts. The study was conducted in Libya's Al-Jabal Al-Akhdar region with 60 participants divided into three groups: non-smokers (control group), tobacco smokers, and cannabis users. The results revealed a statistically significant relationship between cannabis use and decreased salivary flow rate along with lower salivary pH levels, creating a more acidic oral environment. Additionally, a marked increase in Lactobacillus bacterial growth and Candida albicans colonization was observed among cannabis users compared to the other two groups. These findings indicate adverse oral health effects that warrant specific public health attention. ......................... Keywords:...............Cannabis, Oral health, Salivary flow rate, Candida albicans, Lactobacillus bacteria, Salivary pH Levels